If you are looking for a game that combines creativity and music (Wii Music also comes to mind), you might want to track down SimTunes from Maxis. It came out in 1996 and seems to be out of print.
"SimTunes is one of those wonderful programs that grows with the user. In essence, it is a paint program that doubles as a musical composition program--or vice versa. The user begins with a blank screen, or canvas and a variety of tools, paints, and patterns with which to decorate said canvas. The twist is that each colored dot applied to the design represents a musical note--from low C to high C. Now add 4 adorable little "bugz" to the painting. The bugz march across the screen much like Pacman. But instead of munching, these bugz make music when they contact a dot.
Each bug is a caricature of the musical instrument it plays. There are a dozen bugz in each of 4 different categories to choose from--some play standard instruments, like pianos and guitars; some play unusual instruments, like steel drums or cymbals; some play chords or riffs, some make sound effects, and some rival Scatman Caruthers in verbosity. The user chooses one bug from each group to create a quirky quartet.
At this point the creative mind is let loose. Some users choose to create non-drawings which sound like actual tunes, known or newly composed. Others choose to create intricate drawings that, when "played" by the bugz result in utter cacophony. With dedication, the user can even create the perfect marriage of art and music. Examples of previous SimTunes users' masterpieces can be found in the "Gallery". The possibilities are endless, and as with any artistic endeavor, beauty is in the eye, or in this case the computer, of the beholder!"